Anti-depressants, anti-anxiety medicines, painkillers, sedatives, allergy medicines and muscle relaxers can increase the sleepy effect of BuSpar.
Notify your doctor of all medications you are taking before starting the course of BuSpar, especially: bosentan; cimetidine; conivaptan; dexamethasone; haloperidol; nefazodone; antibiotics such as erythromycin (E.E.S., EryPed, Erythrocin), clarithromycin (Biaxin), rifampin (Rifater, Rifadin, Rifamate), rifapentine (Priftin), rifabutin (Mycobutin) or telithromycin (Ketek), antifungal drugs such as ketoconazole (Nizoral), itraconazole (Sporanox), voriconazole (Vfend) or posaconazole (Noxafil); barbiturates e.g. secobarbital (Seconal), butabarbital (Butisol), phenobarbital (Solfoton) or pentobarbital (Nembutal); hepatitis C medications telaprevir (Incivek) or boceprevir (Victrelis), narcolepsy medications such as modafinil (Progivil) or armodafinil (Nuvigil); medications to treat seizures such as oxcarbazepine (Trileptal), primidone (Mysoline) or carbamazepine (Equetro, Carbatrol Tegretol); heart or blood pressure medication such as verapamil (Calan, Covera, Isoptin, Verelan) or diltiazem (Tiazac, Cartia, Cardizem); HIV/AIDS medications e.g. etravirine (Intelence), efavirenz (Sustiva, Atripla), nelfinavir (Viracept), indinavir (Crixivan), nevirapine (Viramune), saquinavir (Invirase) or ritonavir (Norvir, Kaletra).
BuSpar can also interact with other medications.